Especially, Be sure that you examine In case you are applying any of the following in advance of taking promethazine/phenylephrine/codeine.
Promethazine/phenylephrine/codeine is often employed to cut back coughing, nasal congestion, along with other symptoms from allergies or typical chilly.
An anticholinergic drugs, which includes antihistamines and medicines usually used for overactive bladder, Parkinson’s ailment, or tummy troubles
Due to the fact recurrences of NMS are described with phenothiazines, the reintroduction of promethazine HCl needs to be cautiously thought of.
People who are sensitive to caffeine ought to consult with their Health care practitioners right before consuming this product. five
When you have been getting promethazine/phenylephrine/codeine often, don't prevent having the medication with out speaking with your Health care supplier. Stopping too promptly might induce severe Unwanted effects. Phone your healthcare company instantly For those who have any of the next indications.
Peripheral Vascular Ailment. Promethazine/phenylephrine/codeine really should not be utilised In case you have peripheral vascular condition, and that is a problem that influences blood vessels. Promethazine/phenylephrine/codeine could make this problem worse.
Animal reproduction reports haven't been done With all the drug mixture – promethazine and codeine. It's not acknowledged no matter whether this drug combination could cause fetal damage when administered to some Expecting woman or can affect replica capability.
It's important here you get rid of undesired opioid medicines safely. Unused medicines might be returned to any pharmacy. Really don't maintain unused codeine 'just in the event that'. This can result in dangerous or inappropriate use.
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Respiratory Difficulties. Promethazine/phenylephrine/codeine may well result in gradual or shallow respiration, especially if you might have respiratory complications from An additional problem or take other medicines that will slow your respiratory.
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NMS is a serious condition that may result in Dying. Stop taking promethazine/phenylephrine/codeine and contact your healthcare provider right away When you've got any of the subsequent signs and symptoms.
Promethazine is nicely absorbed with the gastrointestinal tract. Clinical effects are clear inside twenty minutes after oral administration and customarily very last 4 to six hrs, Despite the fact that They might persist assuming that 12 several hours. Promethazine is metabolized via the liver to a variety of compounds; the sulfoxides of promethazine and N-demethylpromethazine will be the predominant metabolites showing up in the urine.